Senior Engineer, Protein & Gene Platform
Email: zhaolx@@shanghaitech.edu.cn
Biography:
2016.5-present Senior Engineer, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, China.
2013.11-2016.5 Senior Engineer, iHuman Institute, ShanghaiTech University, Shanghai, China.
2009.12-2013.10 Postdoctoral Fellow, Research Assistant Professor, Institute of Biophysics, CAS, Beijing, China.
2006.11-2009.11 Postdoctoral Fellow, Academy of Military Medical Science, Beijing, China.
2006 Ph.D. in Genetics, Academy of Military Medical Science, Beijing, China.
2003 M.S. in Biochemistry and Molecular Biology, Shanxi University, Shanxi, China.
2000 B.S. in Biochemistry, Shanxi University, Shanxi, China.
Representative publication:
1. Zhao L*, Xu L*, Zhou X, Zhu Q, Yang Z, Zhang C, Zhu X, Yu M, Zhang Y, Zhao X, Huang P. Interaction of influenza virus NS1 protein with growth arrest specific protein 8. Virol J, 2009, 6(218). (*Co-first authors)
2. Zhang Y, Zhou X, Zhao L, Li C, Zhu H, Xu L, Shan L, Liao X, Guo Z, Huang P. UBE2W interacts with FANCL and regulates the monoubiquitination of fanconi anemia protein FANCD2. Mol Cells, 2010, 31(2): 113–122.
3. Ouyang S*, Gong B*, Li J*, Zhao L*, Wu W, Zhang F, Sun L, Wang S, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao G, Wang Y, Liu Z, Liang M. Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus. J Mol Med, 2012, 90: 837-846. (*Co-first authors)
4. Ru H*, Zhao L*, Ding W*, Jiao L, Shaw N, Liang W, Zhang L, Hung L, Matsugaki N, Wakatsuki S, Liu ZJ. The S-SAD phasing study of DR6 and its solution conformation revealed by SAXS. Acta Crystallogr D, 2012, 68:521–530. (*Co-first authors)
5. Ru H*, Ni X*, Zhao L*, Crowley C, Ding W, Hung L, Shaw N, Cheng G, Liu ZJ. Structural basis for termination of AIM2-mediated signaling by p202. Cell Res, 2013, 23(6):855-858. (*Co-first authors)
6. Zhao L*, Hua T*, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung L, Huang W, Liu L, Ye K, OuYang S, Cheng G, Liu ZJ. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res, 2014, 24(3):344-58. (*Co-first authors)
7. Ni X*, Ru H*, Ma F*, Zhao L*, Shaw N, Feng Y, Ding W, Gong W, Wang Q, Ouyang S, Cheng G, Liu ZJ. New insights into the structural basis of DNA recognition by HINa and HINb domain of IFI16. J Mol Cell Biol, 2016, 8(1):51-61. (*Co-first authors)
8. Lv X, Liu J, Shi Q, Tan Q, Wu D, Skinner J, Walker A, Zhao L, Gu X, Chen N, Xue L, Si P, Zhang L, Wang Z, Katritch V, Liu ZJ, Stevens RC. In vitro expression and analysis of the 826 human G protein-coupled receptors.Protein Cell, 2016, 7(5):325–337.
