| | Lu Zhang Ph.D. | Assistant Professor Principal Investigator Institute Shanghai Institute for Advanced Immunochemical Studies School of Life Science and Technology Research Area Structural biology, Glycobiology, drug development based on three-dimensional structure of the drug target Contact Info. zhanglu1@shanghaitech.edu.cn --------------------------------------------------------------------------------------------------------------------------------------------------------------- Education 2001-2005 Bachelor degree student in Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, China 2005-2008 Master degree student in Microbiology, College of Life Sciences, Nankai University, China 2016-2019 PhD degree student in Biochemistry and Molecular Biology under supervisor of Prof. Zihe Rao, College of Life Sciences, Nankai University, China, also a visiting collaborating PhD student at the ShanghaiTech University.
--------------------------------------------------------------------------------------------------------------------------------------------------------------- Working Experience
2008-2016 Working as a professional staff in the College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Ministry of Science and Technology, China (2011-2013) 2020-now Assistant professor in School of Life Science and Technology, PI in Shanghai Institute for Advanced Immunochemical Studies (SIAIS) ---------------------------------------------------------------------------------------------------------------------------------------------------------------
Research Interests
(i) Structural study of drug target proteins involved in Mycobacterium Tuberculosis cell wall synthesis and structure based new anti-Tuberculosis drug development; (ii) Structural and functional studies of disease-related membrane-bound glycosyltransferases (GTs). Dr. Lu Zhang has contributed to determining the three dimensional structures of multi-pass transmembrane proteins and protein complexes related to drug targets of infectious diseases (i.e. Mycobacterium Tuberculosis) by comprehensively using cryo-EM and X-ray crystallography; concentrated on the glycobiological and biochemical strategy of understanding the functions of membrane-bound glycosyltransferases (GTs). She has now opted for developing new anti-tuberculosis drugs based on 3D structures of the drug targets. --------------------------------------------------------------------------------------------------------------------------------------------------------------- Selected Publications Zhang, Lu*; Zhao, Yao*; Gao, Yan; Wu, Lijie; Gao, Ruogu; Zhang, Qi; Wang, Yinan; Wu, Chengyao; Wu, Fangyu; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Zhao, Wei; Qin, Ling; Yang, Xiuna; Wang, Manfu; Zhu, Yan; Zhang, Bing; Bi, Lijun; Zhang, Xian'en; Yang, Haitao; Guddat, Luke W.; Xu, Wenqing; Wang, Quan#; Li, Jun#; Besra, Gurdyal S.#; Rao, Zihe#.Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. SCIENCE. 12 Jun 2020. 368(6496):1211. Zhang, Lu*; Zhao, Yao*; Gao, Ruogu*; Li, Jun; Yang, Xiuna; Gao, Yan; Zhao, Wei; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Besra, Kajelle Kaur; Xu, Wenqing; Bi, Lijun; Zhang, Xian'en; Guddat, Luke W.; Yang, Haitao; Wang, Quan#; Besra, Gurdyal S.#; Rao, Zihe#.Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2). PROTEIN & CELL. 03 May 2020. Zhang, Bing*; Li, Jun#; Yang, Xiaolin; Wu, Lijie; Zhang, Jia; Yang, Yang; Zhao, Yao; Zhang, Lu; Yang, Xiuna; Yang, Xiaobao; Cheng, Xi; Liu, Zhijie; Jiang, Biao; Jiang, Hualiang; Guddat, Luke W.; Yang, Haitao#; Rao, Zihe#.Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. CELL. 24 Jan 2019. 176(3):636-+.
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